Further, autocrine production of pro-HGF by tumor cells is also observed in multiple tumors (Fukuura et al., 1998; Seidel et al., 1998; Porta et al., 2013; Liu, 2015) and HGF is essential for the crosstalk between tumor cells and stromal cells (Gherardi et al., 2006; Luraghi et al., 2014; Pallangyo et al., 2015). This evidence concerns the gene HGF and neoplasm.