SETDB1 and colorectal cancer: In colorectal cancer cells, TIP60 also exerts an anti-inflammatory response by activating the expression of SUV39H1 and SETDB1, two histone H3K9 methyltransferases, which in turn repress the transcription of retrotransposon elements to contain STING/IRF7-mediated inflammation (Rajagopalan et al., 2018).