SOX2 and colonic neoplasm: Takeda et al. (2018) have shown that SOX2+ cells developed chemoresistance to oxaliplatin and 5-FU, exhibiting typical asymmetric cell division and higher CSC markers expression. They concluded that colon cancer cells expressing SOX2 behave like CSCs and are therefore associated with poor prognosis (Lundberg et al., 2016; Takeda et al., 2018).