Familial ALS is caused due to mutations in the genes encoding for the antioxidant protein superoxide dismutase 1 (SOD1), the TAR-DNA binding protein 43 (TDP43), ubiquilin 2 (Ubqln2), and VAPB (De Mario et al., 2017; Perrone et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.