CCNE1 and triple-negative breast carcinoma: However, levels and activity of miR-195 were recently shown to be also dependent on a sponging circular RNA, circAGFG1, in triple-negative breast cancer; of note, circAGFG1 is able to cause Cyclin E1 (CCNE1) upregulation as a consequence of miR-195 sequestering (Yang et al., 2019).