TP53 and malignant colon neoplasm: Initially, miR-107 has been identified as a transcriptional target of p53 by Yamakuchi et al. (2010), who showed in colon cancer cells that p53, by inducing miR-107 expression, negatively impacts on angiogenesis, thanks to the ability of miR-107 to target HIF-1beta (also known as ARNT).