Otahal et al. demonstrated in vitro the effectiveness of the combination of fluvastatin or pitavastatin with erlotinib, an approved EGFR tyrosine kinase inhibitor (EGFR-TKI), in EGFR-TKI resistant human lung adenocarcinoma cell lines with mutated or overexpressed EGFR, such as A549, Calu6, and H1993, exhibiting promising cytotoxic effects. The gene discussed is EGFR; the disease is lung adenocarcinoma.