These post-translational modifications are critical for the downstream signaling activity of Ras, Rho, or Rac proteins, that are part of the small GTPases superfamily (Takai et al., 2001), involved in tumorigenesis, progression (Buhaescu and Izzedine, 2007), proliferation, migration, and survival of tumor cells (Kidera et al., 2010). The gene discussed is RHO; the disease is neoplasm.