FFAR2 and obesity due to melanocortin 4 receptor deficiency: In terms of the potential way of these SCFAs producers to regulate the intergenerational effects, a recent study determined that SCFAs such as acetate, propionate, and butyrate from maternal gut microbiota during pregnancy can be sensed by their receptors GPR41 and GPR43 in the embryonic intestinal tract and pancreas, which impacted the development of the metabolic system and programmed offspring resistance to obesity.