Our research data indicated that (1) high FOXO3a expression predicts a higher survival rate for cervical carcinoma patients; (2) FOXO3a overexpression is associated with higher tumor stage and grade and nodal involvement in cervical carcinoma patients but is not associated with age, histologic type, tumor size, or recurrence status; (3) FOXO3a expression is decreased in cervical carcinoma tissue compared to normal tissue, and it correlates negatively with β-catenin expression; and (4) FOXO3a depletion promotes cell invasion and migration via WNT/β-catenin pathway in cervical carcinoma. Here, FOXO3 is linked to neoplasm.