FOXO3 and metastatic malignant neoplasm in the lymph nodes: The multivariate analysis showed that FIGO stage (HR 1.991, P = 0.033), lymph node metastasis (HR 2.029, P = 0.027) and FOXO3a expression (HR 2.218, P = 0.015) were significantly associated with 5-year OS (Table 2).