In the current study, FOXO3a knockdown resulted in significantly higher expression levels of MMP2, MMP9, Survivin, cyclin D1, c-myc, and β-catenin and lower GSK3β levels compared with the levels in the control vector group, suggesting an inhibitory effect of FOXO3a on cervical carcinoma cell invasion and migration. This evidence concerns the gene MMP9 and cervical carcinoma.