Finally, β-catenin silencing in breast cancer cells decreases mRNA levels of the peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), mitochondrial transcription factor A (TFAM), nuclear respiratory factor-1 (Nrf1), and GLUT-1, thus increasing levels of acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), and sterol regulatory element-binding protein 1 (Srebp1) (85). The gene discussed is TFAM; the disease is breast carcinoma.