In this observational and prospective study, we found the following: I-) PAF patients had lower Apo-A1 levels than healthy participants II-) there was no any relation between Apo-A1 levels and AF attacks, AF duration, and the LA diameter in patients with PAF III-) this study result might provide evidence that Apo-A1 levels might have an important role in the pathophysiology of AF. Here, APOA1 is linked to atrial fibrillation.