As mentioned, several studies report that angiogenesis inhibition is associated to NF-κB activation.29 In contrast to the inhibition effects of NF-κB on angiogenesis, recent reports suggest that in certain situations NF-κB can promote angiogenesis.30 In our unpublished research, we showed that NF-κB levels were increased in diabetes and exercise reversed this effect and promoted angiogenesis in sciatic nerve of diabetic rats in exercise group. Here, NFKB1 is linked to diabetes mellitus.