The expression of five genes (EMCN, engulfment and cell motility 1, solute carrier organic anion transporter family member 2A1, potassium voltage-gated channel subfamily A member regulatory beta subunit 1, and inter-alpha-trypsin inhibitor heavy chain 5) decreased in FTC compared with benign follicular thyroid adenoma (FTA), and the 5-gene classifier has high specificity and sensitivity and can be used to distinguish FTC from FTA [37]. This evidence concerns the gene KCNAB1 and follicular thyroid adenoma.