However, elevated levels of NPs (BNP ≥ 100 pg/ml or NT − proBNP ≥ 300 pg/ml; or BNP ≥ 300 pg/ml or NT − proBNP ≥ 900 pg/ml if in atrial fibrillation/flutter) in patients with suspected HFmrEF/HFpEF were found to confirm the diagnosis [182]. This evidence concerns the gene NPPB and atrial fibrillation.