Thus, clinical prediction models for HF-related outcomes based on various biomarkers of biomechanical stress (NT-proBNP, copeptin, midregional proadrenomedullin (MR-proADM), and growth/differential factor- (GDF-) 15), inflammation (high-sensitivity C-reactive protein), and fibrosis (galectin-3, soluble ST2) were only improved marginally by the addition of hs-TnT/hs-TnI. Here, NPPB is linked to hydrops fetalis.