RYR2 and melanoma: RYR2 is a member of the RyR gene family and has been to be associated with several cancers like melanoma, breast, lymphoma etc. It has been also been established that RYR2 functionally regulates Ca2+ release from sarcoplasmic reticulum into the cytosol and Ca2+ levels effects transcription, vesicle secretion, cell proliferation and apoptosis.