RYR2 and ovarian cancer: Of the 16 genes that were frequently mutated or had copy-number changes in the ovarian cancer samples (Figure 4A and 4C), 5 were transcriptionally overexpressed in the cancer tissues (PIK3CA (39.41%), TTN (8.47%), RYR2 (10.1%), KMT2C (13.03%), and KRAS (23.13%)), and 2 were strongly repressed at the mRNA level (PTEN (13.03%) and ARID1A (8.47%); Figure 5B and 5C).