RYR2 and female reproductive organ cancer: Other genes that were mutated at frequencies of 10% or higher among the gynecological cancer samples were AT-rich interactive domain-containing protein 1A (ARID1A), mucin 16 (MUC16), phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1), histone-lysine N-methyltransferase 2D (KMT2D), CUB and sushi multiple domains 3 (CSMD3), ryanodine receptor 2 (RYR2), catenin beta-1 (CTNNB1), F-box/WD repeat-containing protein 7 (FBXW7), usherin (USH2A), lysine N-methyltransferase 2C (KMT2C), spectrin repeat-containing nuclear envelope protein 1 (SYNE1), and KRAS proto-oncogene (KRAS) (Figure 3A).