As displayed in Figure 2 and compared with its value in normal tissues, PRKACB was significantly downregulated in rectal adenocarcinoma (P<0.0001, Figure 2B), rectal carcinoma (P<0.0001, Figure 2G), colon carcinoma (P<0.0001, Figure 2E-G), colon adenoma (P<0.0001, Figure 2E), colorectal carcinoma (P<0.0001, Figure 2C-D), and colorectal adenocarcinoma (P<0.0001, Figure 2D). The gene discussed is PRKACB; the disease is rectal carcinoma.