Studies at home and abroad have shown that the expression of HIF-1 α is regulated by many signaling pathways, among which the activation of mammalian rapamycin target (mTOR) related signaling pathway can increase the expression of HIF-1 α, maintain the acidic microenvironment of tumors, improve the invasion and metastasis of tumor cells, and lead to poor prognosis of solid tumors 10, 11. Here, SETD2 is linked to neoplasm.