Then, we found that eIF4E siRNA suppressed the expression of HIF-1α, whereas the expression of eIF4E was inhibited by the mTORC1 siRNA, suggesting that the mTORC1/eIF4E pathway participates in regulating the expression of HIF-1α in primary human glioma culture cells under hypoxia. This evidence concerns the gene HIF1A and central nervous system cancer.