Both in SD rat brain C6 glioma transplantation model and human primary glioma cell model, results showed that borneol could inhibit the expression of mTORC1/eIF4E/HIF-1a pathway, implying that borneol could induce primary glioma cells apoptosis by suppressing HIF-1 α expression via the mTORC1 / eIF4E pathway. Here, SETD2 is linked to central nervous system cancer.