We found that borneol could downregulate the expression of Bcl-2 and upregulation the expression of Bax and caspase-3, borneol could downregulate the expression of Bcl-2 and upregulation the expression of Bax and caspase-3, similarly, the effect was also reversed after transfection of HIF-1 overexpression plasmid, suggesting that the apoptosis effect induced by borneol in human primary cultured glioma cells is mediated via HIF-1α. The gene discussed is SETD2; the disease is glioma.