Furthermore, modulation of STAT3 activity by AG490 and IL-6 restored the H19 dysregulation-induced changes in cell migration and invasion (Figure 4C), the chemosensitivity to gemcitabine (Figure 4D), and the percentage of the CD24+CD44+ESA+ cell subfraction (Figure 4E) in PC cell lines. This evidence concerns the gene STAT3 and pachyonychia congenita.