AKT1 and colorectal carcinoma: To investigate the role of PI3K/Akt signaling in hypoxic CRC cells-secreted exosomes-induced tumor progression, treatment of LY294002, a PI3K inhibitor, markedly blocked HT29 cells progression induced by miR-410-3p mimics and hypoxic HT29 cells-derived exosomes (Figure 4J-L).