FGFR1 and small cell lung carcinoma: The majority of the studies used FISH to detect the FGFR1 amplification; the frequency of FGFR1 amplification in prior SCLC studies was 5.6-7% by FISH 16,32 or 7.8% by silver in situ hybridization (SISH) 8 in Western population with SCLC.