FGFR1 and lung carcinoma: Until Wynes et al. demonstrated that expression FGFR1 mRNA is a biologically relevant marker of FGFR1 TKI sensitivity in lung cancers of all histologies, including squamous, adenocarcinoma, and SCLC among 58 cell lines in vitro10, it was grew in awareness that FGFR1 amplification may not be the right biomarker to predict response 33.