As we depict in the graphic hypothesis (Figure 6) summarizing findings reported here, and in a previous study using the same model (10), the Kyn pathway has a complex role in immunologic and neurologic processes driving autoimmunity and comorbidities during EAE disease progression and responses to STING agonist treatments to alleviate EAE. The gene discussed is STING1; the disease is Autoimmunity.