Similar to human MDS, the NHD13 mice (expressing the NUP98-HOXD13 fusion from the hematopoietic Vav-1 promoter) display cytopenias, bone marrow dysplasia, and increased HSPC cell death, and the mice die of acute leukemia (predominately myeloid) or bone marrow failure by about a year of life (117). The gene discussed is NUP98; the disease is myelodysplastic syndrome.