Further implicating TLR signaling in the promotion of pyroptotic cell death in MDS, we recently reported that loss of TLR2 or MyD88 in the NUP98-HOXD13 (NHD13) mouse model of MDS led to a reduction in premalignant cell death and more rapid leukemic transformation (116). The gene discussed is HOXD13; the disease is myelodysplastic syndrome.