CASP1 and myelodysplastic syndrome: In a recent study, Basiorka et al. (82) reported that markers of pyroptosis (activated caspase-1, NLRP3, and ASC speck levels) were higher in the bone marrow mononuclear cells (BM-MNCs) of patients with MDS compared to healthy controls, and cell death was inhibited by shRNA-mediated knockdown of NLRP3 or caspase- 1.