Silica increased Bregs on days 7, 28, and 56 post-exposure in mice; anti-CD22 attenuated Breg response, which ↑ inflammation, ↓ fibrosis, with ↑ Th1 response, ↓ Treg, Th17, and Th2 responses  Patients with silicosis had significantly ↑ serum IL-10, IL-4, IL-5, and IL13; & ↑ Breg (CD19+ CD1dhigh CD5+ IL-10+), Treg, and Th2 in the blood. The gene discussed is IL4; the disease is silicosis.