The HIV infection process involves several stages from the binding of virions to receptors on the human CD4+ cell surface to the splicing and export of viral mRNAs from the nucleus to the cytoplasm, and the assembly of virions at the plasma membrane as well as the budding and maturation of the released virions (Kirchhoff, 2013; Chen et al., 2018). Here, CD4 is linked to HIV infectious disease.