Given AMPK closely links to a diverse metabolic axis in the body, it shall be reasonable to have a better understanding of the implication of oxidative stress and AMPK-Nrf2 anti-oxidative signaling in inflammatory pathogenesis, and to further explore the therapeutic potential of AMPK-Nrf2 signaling on metabolic and endocrine disorder-impacted pulmonary diseases. This evidence concerns the gene NFE2L2 and endocrine system disorder.