PRKAA2 and type 2 diabetes mellitus: It has also been reported that in T2D model mice treated with cassia seed extract, the mRNA and protein expression levels of P-LKB1, P-AMPKa12, AMPKa2, P-AMPKa2, GLUT4 are increased, which means the glucose transport pathway is restored, results in glutathione levels increased and ROS levels decreased significantly (151).