In the latest research conducted by Vincent Munster et al., the author created various COVID-19 pseudotypes with spikes from different lineage B coronaviruses, some of which infect animals, and revealed that the absence of 431–437 and 456–473 residues in the RNA coding sequence of receptor binding domain, which is widely observed in betacoronaviruses that infect non-human animals, deprived the infectivity of modified COVID-19 to infect cells overexpressed human angiotensin-converting enzyme 2 (hACE2), the receptor for COVID-19 (21). The gene discussed is ACE2; the disease is COVID-19.