Studies in animal models of Alzheimer's disease (AD) revealed that ascorbic acid could restore behavioral deficits, memory impairment, and the reduction in brain synaptophysin, as well as reduce the formation of amyloid-β oligomers, phosphorylation of Tau at Ser39, oxidative stress markers, and proinflammatory cytokines (31–34). Here, MAPT is linked to Alzheimer disease.