Renin enzyme can reach the proximal tubule that express angiotensinogen, angiotensin-I converting enzyme (ACE), and AT1 receptors in the apical domain of proximal tubule and distal convoluted tubule producing angiotensin II that contributes to hypertension through the stimulation of NaCl reabsorption in the proximal and distal convoluted tubule (Velez, 2009; Gurley et al., 2011; Li et al., 2018). The gene discussed is REN; the disease is hypertensive disorder.