In our study, we treated MDA-MB-231 and 4T1 cells with DXL and we observed that the activations of survivin and Bcl-2 were increased and the level of p-IκBα was a little upregulated, which indicated that DXL induced the chemo-resistance of pancreatic cancer cells. The gene discussed is NFKBIA; the disease is pancreatic neoplasm.