Since microglia have been proposed to contribute to the HD pathological process, and the FKN-CX3CR1 axis has a central role in controlling microglial activity, we first analyzed the effects of mHtt on CX3CR1 and FKN expression in the striatum of R6/1 mice at different ages (1, 8, 12, 20, and 30 weeks of age). Here, CX3CR1 is linked to Huntington disease.