TFRC and ischemic stroke: An increasing number of recent studies confirmed that free iron accumulates in the ipsilateral hypoxic-ischemic neonatal rat cortex (Palmer et al., 1999), total iron is increased significantly in the ischemic areas after ischemic stroke (Tuo et al., 2017), and the levels of transferrin receptors (TfRs) and iron-loaded transferrin (holo-transferrin, HTf) also increase after ischemic stroke (Park et al., 2011; DeGregorio-Rocasolano et al., 2018).