GPX4 and hemorrhagic stroke: A recent study indicated that pharmacological selenium (Se) effectively inhibits GPX4-dependent ferroptosis and attenuates the cell death induced by excitotoxicity or ER stress, which is are GPX4 independent processes, via the coordinated activation of the transcription factors TFAP2c and Sp1 to protect neurons after hemorrhagic stroke (Alim et al., 2019).