PRKAA1 and Parkinson disease: Animal studies reported the beneficial effect of MTF in murine models of PD through an AMPK energy equilibrating pathway (Patil et al., 2014), macroautophagic activation (Labuzek et al., 2010a; Lu et al., 2016; Katila et al., 2017), antioxidant (Patil et al., 2014; Lu et al., 2016), and anti-inflammatory actions (Labuzek et al., 2010b; Bayliss et al., 2016).