However, primary dopaminergic neurons from G2019S LRRK2 and non-transgenic mice showed no difference in levels of aggregated phosphorylated S129 α-synuclein 21 days post-transduction with PFF, indicating LRRK2 does not worsen α-synuclein pathology in dopaminergic neurons which are more relevant to PD. The gene discussed is LRRK2; the disease is Parkinson disease.