The targeted relationship between miR-15a-5p and PVT1 or KIF23 was validated, and we found that PVT1 regulated the expression of KIF23 through miR-15a-5p, suggesting the regulatory effects of PVT1/miR-15a-5p/KIF23 axis in the progression of PCa. Here, PVT1 is linked to posterior cortical atrophy.