APC and cancer: Next, we compared the genes affected in recurrently altered chromosomal regions with the Cancer Gene Census database and identified the following high-risk genes: APC, ATP1A1, BCL10, CTNNB1, FAM46C, FUBP1, HLA-A, JAK1, NOTCH2, NRAS, RBM15, RPL5, TRIM33, and VAV1.