At present, nucleos(t)ide analogues (NAs) [such as entecavir (ETV), tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF)] and interferon-α (IFNα), are used for the treatment of chronic hepatitis B (CHB) 2. Here, IFNA2 is linked to chronic hepatitis B virus infection.