NFKB1 and plasma cell myeloma: A study in myeloma cells with KPT-185 or KPT-330 shows changes in cell cycle regulators and apoptosis, nuclear accumulation of p53, p27, p21 and FOXO3A, nuclear accumulation of IkB, affecting NF-kB signaling, reduction in c-MYC and antiapoptotic proteins Mcl-1 and Bcl-xL and increase in mRNA of stress response proteins [11, 13].