The suppression of galectin-3 downregulated the activation of mTOR and S6K in colon cancer.18 In this study, we used CAGE analysis to identify mTOR signaling as a downstream effector of M2BPGi in HCC, and validated that M2BPGi could bind to galectin-3 and activate mTOR signaling in HCC cells through both in vitro and in vivo experiments. Here, RPS6KB1 is linked to hepatocellular carcinoma.