Traits where the PRS were significantly associated with ↑WS depression compared to non-↑WS depression included BMI [OR = 1.20 (1.15–1.26), p = 2.37 × 10−14], CRP [OR = 1.11 (1.06–1.17), p = 8.86 × 10−06], daily alcohol use [OR = 0.88 (0.83–0.93), p = 1.04 × 10−05] and MDD [OR = 1.10 (1.05–1.15), p = 1.14 × 10−04], as shown in Table 1 (see online Supplementary Table S2 for all results). This evidence concerns the gene CRP and depressive symptom measurement.