The analyses of individual symptoms (weight changes and sleep changes) showed that BMI, non-BMI adjusted leptin and CRP PRS had a higher effect size on depression with weight increase than sleep increase, but not the PRS of alcohol daily use and MDD; however, the direction of the effect on weight and sleep increase was the same for all these PRS, suggesting that the symptoms of weight gain and sleepiness in depression have shared rather than divergent genetics. Here, LEP is linked to depressive disorder.