The OR for ↑WS depression was 2.03 (1.62–2.55), 1.36 (1.10–1.68), 0.62 (0.49–0.79) and 1.30 (1.04–1.61) in the 10th PRS decile v. the 1st PRS decile for BMI, CRP, daily alcohol use and MDD, respectively (Fig. 2). This evidence concerns the gene CRP and depressive disorder.