There are no doubts about the pivotal role of decorin as an inhibitor of tumorgrowth and metastasis.77 This is based on the ability of decorin to engage multiple receptortyrosine kinases and to act as a signaling molecule regulating angiogenesis.86 Even though the relationship between inflammation, immunity, and canceris well established,87 studies addressing decorin-dependent regulation of tumor inflammation arestill required. The gene discussed is DCN; the disease is neoplasm.