In a model of tumor xenograft growth, adenovirus-mediated overexpression ofdecorin causes TLR2/TLR4-driven synthesis of PDCD4, TNF-α and IL-12, andTGF-β1/miR-21-mediated inhibition of PDCD4 suppression.12 In consequence, the immune reaction is shifted to a more apoptotic andinflammatory response with strong anti-tumorigenic effects, resulting in amarked retardation of tumor growth.12 This, along with the enhancement of the tumor suppressor PDCD4 and thereduction of the oncogene miR-21, might represent an attractive approach forcancer therapy. The gene discussed is TLR4; the disease is neoplasm.