Decorin-driven inflammatory signaling was verified in vivo in sepsis and tumor xenografts.12 In LPS-induced septic mice, high levels of decorin mRNA and protein aredetected in septic lungs and macrophages.12 In contrast, decorin deficiency in septic mice leads to reduced PDCD4abundance and enhanced expression of miR-21 and IL-10, which are associated withattenuated pro-inflammatory responses. The gene discussed is DCN; the disease is Sepsis.