Remarkably,analysis of the global gene expression profile of the tumor microenvironment ina triple-negative orthotopic breast carcinoma xenograft model revealed that theleukocyte chemotactic and inflammatory genes are the most significantlydownregulated by decorin protein core (Fig. 2).96 It is of note that these findings are not contrary to other reportsidentifying decorin as a pro-inflammatory SLRP. Here, DCN is linked to breast carcinoma.