AKT1 and Burkitt lymphoma: Indeed, Spender et al. [30] reported that PI3K/AKT or c‐MYC inhibition by specific agents strongly increased ABT‐737‐induced apoptosis in BL cells, suggesting that both the PI3K pathway and c‐MYC are involved in the relative resistance of BL cells to BCL‐2/BCL‐xL inhibition.