In logistic models, ApoE e4e4 genotype was associated with increased risks of test positivity (OR = 2.24, 95% CI: 1.72–2.93, p = 3.24 × 10−9) and of mortality with test-confirmed COVID-19 (OR = 4.29, 95% CI: 2.38–7.72, p = 1.22 × 10−6), compared to e3e3s. This evidence concerns the gene APOE and COVID-19.