Moreover, after adjustment for age, sex, current smoking, hypertension, DM, previous stroke, and coronary heart disease, this significant relationship was also observed for other lipid ratios (TC/HDL-C, [β] 0.71, [OR] 2.04, [95% CI] 1.26–3.31; RC/HDL-C, 0.49, 1.64, 1.01–2.65; non-HDL-C/HDL-C, 0.71, 2.04, 1.26–3.31; LDL-C/HDL-C, 0.65, 1.92, 1.19–3.10; apo B/HDL-C, 0.83, 2.28, 1.41–3.71; fourth quartile vs. first quartile; see Fig. 1a and Supplementary Table 3). This evidence concerns the gene APOB and Hypertension.