The present study shows high circulatory Lcn2 in murine NASH, and these levels in the circulation may induce expression of inflammatory receptors and Lcn2 receptor 24p3R in brain tissues of NASH mice, thus raising the possibility of an altered neuroinflammatory pathology in the brain of NASH mice. The gene discussed is LCN2; the disease is metabolic dysfunction-associated steatohepatitis.