AKT1 and neoplasm: In vitro studies on anticancer activity of mistletoe have confirmed that it modulates many different pathways, playing key roles in tumour proliferation, including MAPK (mitogen-activated protein kinase) (Park et al. 2012) and PI3K/AKT (phosphatidylinositol 3-kinase/protein kinase B) (Fan et al. 2019).