Several plasma biomarkers were identified some of which were significantly up-regulated (Hemopexin, Haptoglobin, Kelch domain-containing protein 8B, E3 ubiquitin-protein ligase HECTD, DNA (cytosine-5)-methyltransferase 3A, Complement C1r subcomponent, Immediate early response 3-interacting protein 1, Integrator complex subunit 10, Complement component C6) other were significantly down-regulated (Ceruloplasmin, Complement C3) in plasma of patients with low grade bladder cancer compared to healthy controls (Table 2). The gene discussed is KLHDC8B; the disease is urinary bladder carcinoma.