When comparing the ability of the stathmin pathway to predict sensitivity to CLTC inhibition with single genes, we found that while a few single genes in the stathmin pathway did also correlate with the essentiality of CLTC in NSCLC cell lines, the stathmin pathway activity score consistently exhibited the highest correlation and area under the ROC curve (Fig. 6d and Supplementary Fig. 8g). This evidence concerns the gene CLTC and non-small cell lung carcinoma.