In addition to C9orf72, genes encoding RNA-binding proteins such as FUS (fused in sarcoma) and TDP-43 (TAR DNA-binding protein 43) are also enriched in ALS/FTD-associated mutations, suggesting that RNA misprocessing may be a converging point in ALS/FTD pathophysiology9,10. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.