With reference to the findings of the pathology examination, SI Figure S4 showed that both the 68Ga-PSMA-617 uptake values (SUVmax or SUVratio) and PI-RADS score were significantly higher in clinically significant PCa (GS ≥ 7) than in non-clinically significant PCa (GS = 6 or benign lesions) (P < 0.0001) (Table 4; SI Figure S4). Here, FOLH1 is linked to posterior cortical atrophy.