When we only considered clinically significant PCa (GS ≥ 7) and chose PI-RADS 4 as the diagnostic selected threshold, the diagnostic accuracy (AUC) of mpMRI went up to 0.761, which was consistent with the previous studies, but still significantly lower than that of 68Ga-PSMA PET/CT. This evidence concerns the gene FOLH1 and posterior cortical atrophy.