Furthermore, the pathological findings of the present study indicated that all tumors were possible prostate adenocarcinomas and did not involve specific types such as neuroendocrine (< 2%) 37 or intraductal carcinoma (< 1%)38, and these special types of tumors often showed lower expression of PSMA, so 68Ga-PSMA-617 PET/CT examinations might be prone to false-negative results39,40 that would interfere with their specificity. Here, FOLH1 is linked to prostate adenocarcinoma.