Without consideration of the limiting PSA cut-off (20 ng/ml), a previous systematic review and meta-analysis by Perera et al.14 reported that the summary sensitivity and specificity of 68Ga-PSMA-11 PET/CT were both 86% in the patient-basis analysis of PCa, and the present study showed slightly higher results for sensitivity and specificity (87.88% and 88.24%). This evidence concerns the gene KLK3 and posterior cortical atrophy.