In another study, Guo et al.38 used microarray analysis to screen differentially expressed genes related to molecules involved in the TGF-β signalling pathway in human hepatocellular carcinoma (HepG2) cells in response to the action of LAAO from Agkistrodon blomhoffii ussensis (Akbu-LAAO)38. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.