A subset of AML cases shows abnormal chromosomal translocations that involve nucleoporin 98 (NUP98) and its fusion partners and components of the epigenetic machinery, such as KDM5A/JARID1A, NSD1, NSD3, LEDGF, BPTF, and PHF233–9. The gene discussed is NUP98; the disease is acute myeloid leukemia.